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Lipase is primarily secreted by the pancreas, which is a vital organ that plays a crucial role in digestion. Once secreted, lipase enters the small intestine, where it functions to break down lipids (fats) into fatty acids and glycerol. This process is essential for the absorption of dietary fats, allowing the body to utilize these nutrients effectively.

The pancreas produces several types of enzymes, including lipase, amylase, and proteases, and releases them into the small intestine to promote digestion. In the context of the digestive system, the small intestine is where the majority of nutrient absorption occurs, highlighting the significance of lipase's role in fat digestion and absorption.

Other options mention locations such as the liver and gallbladder, which are involved in the production and storage of bile – important for fat emulsification but not for lipase secretion. The stomach does produce some lipase, but it is in significantly lesser amounts compared to what the pancreas produces. The large intestine and rectum do not play a role in fat digestion and thus are not relevant to the secretion of lipase.

Understanding this process underscores the importance of the pancreas and small intestine in the digestion and absorption of nutrients, particularly dietary fats.